HCID 131726791, compound → HCID 131726794, compound

HRID 1391417Notes

Reaction equation

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:25](ON1C(=O)CCC1=O)=[O:26])[CH2:16][CH2:17][C:18](=[O:24])[O:19]C(C)(C)C)=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6]C(C)(C)C.[NH2:42][C@H:43]([C:48]([OH:50])=[O:49])[C@H:44]([CH2:46][CH3:47])[CH3:45].[CH3:51][N:52]1[C@@H:69]2[CH2:70][C:57]3[CH:58]=[CH:59][C:60]([O:71][CH3:72])=[C:61]4[O:62][C@H:63]5[C:64]([CH2:66][CH2:67][C@@H:68]2[C@:55]5([C:56]=34)[CH2:54][CH2:53]1)=[O:65]>>[NH2:1][C@H:2]([C:12]([NH:14][C@H:15]([C:25]([NH:42][C@H:43]([C:48]([OH:50])=[O:49])[C@H:44]([CH2:46][CH3:47])[CH3:45])=[O:26])[CH2:16][CH2:17][C:18](=[O:19])[OH:24])=[O:13])[CH2:3][CH2:4][C:5](=[O:6])[OH:11].[CH3:51][N:52]1[C@@H:69]2[CH2:70][C:57]3[CH:58]=[CH:59][C:60]([O:71][CH3:72])=[C:61]4[O:62][C@H:63]5[C:64]([CH2:66][CH2:67][C@@H:68]2[C@:55]5([C:56]=34)[CH2:54][CH2:53]1)=[O:65]

Participants

Reactant 2

HCID 131726791HCID 131726791, compound

HCID 131726793HCID 131726793, compound

Product 1

HCID 131726794HCID 131726794, compound

Procedure

Glu-Glu-Ile-Hydrocodone was prepared by similar methods except the amino acid starting material was Boc-Glu(OtBu)-Glu(OtBu)-OSu and the conjugate starting material was Ile-Hydrocodone.

Sources & evidence

ORD record: ord-0b69b7c2842243fc864ac258012603ef
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07338939B2

Reaction notes

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