Hydrochloric Acid → (RS)-S-[4-({5-bromo-4-[(R)-(2-hydroxy-1,2-dimethylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-methyl Sulfoximide

Participants

Reaction Conditions

Reaction Steps

600 mg (2.48 mmol) of (RS)-S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-methyl sulfoximide and 610 mg (2.07 mmol) of (R)-3-[(5-bromo-2-chloropyrimidin-4-yl)amino]-2-methyl-butan-2-ol in 8 ml of acetonitrile are mixed with 0.52 ml of water and 0.52 ml of a 4N solution of HCl in dioxane. The batch is stirred for 24 hours at 60° C. and then concentrated by evaporation. The remaining residue is purified by chromatography (DCM/EtOH 8:2). 649 mg (1.30 mmol, corresponding to 53% of theory) of the product is obtained.

Provenance & Evidence