反应详情

温度

-78 °C

32.7 g (159 mmol) of copper(I)bromide dimethyl sulfide complex is introduced under nitrogen atmosphere into 1000 ml of diethyl ether and cooled to −78° C. Over a period of about 25 minutes, 200 ml of a 1.6 molar solution of methyllithium in diethyl ether is added in drops, and then the cooling bath is removed. The batch is stirred for 40 minutes, and the temperature increases to −35° C. It is cooled to −55° C., and 18.9 g (71.5 mmol) of (R)-2-[(5-bromo-2-chloropyrimidin-4-yl)amino]propanal is added over a period of 20 minutes. It is stirred for 6 hours at −55° C., then the cooling bath is filled with dry ice again, covered with aluminum foil, and the batch is stirred overnight. 200 ml of a saturated ammonium chloride solution is added in drops, and the batch is heated to room temperature. It is diluted with 500 ml of diethyl ether, the organic phase is separated, and the aqueous phase is extracted with diethyl ether. The combined organic phases are washed with saturated ammonium chloride solution and saturated NaCl solution, dried (Na2SO4), filtered and concentrated by evaporation. The remaining residue is purified by chromatography (hexane/ethyl acetate: 4:1-1:1). 8.4 g (30.0 mmol, corresponding to 42% of theory) of the product is obtained.

1. customthe cooling bath is removed
2. temperaturethe temperature increases to −35° C
3. temperatureIt is cooled to −55° C.
4. stirringIt is stirred for 6 hours at −55° C.
5. stirringthe batch is stirred overnight
6. temperaturethe batch is heated to room temperature
7. customthe organic phase is separated
8. extractionthe aqueous phase is extracted with diethyl ether
9. washThe combined organic phases are washed with saturated ammonium chloride solution and saturated NaCl solution
10. dry with materialdried (Na2SO4)
11. filtrationfiltered
12. concentrationconcentrated by evaporation
13. customThe remaining residue is purified by chromatography (hexane/ethyl acetate: 4:1-1:1)
14. custom8.4 g (30.0 mmol, corresponding to 42% of theory) of the product is obtained