Acetic Acid → HCID 178504606, 화합물

HRID 1391466노트

반응식

HRID 1391466 반응식
[Br:1][C:2]1[C:3]([OH:17])=[N:4][C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([S:15][CH3:16])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.C(O)(=[O:20])C>>[Br:1][C:2]1[C:3]([OH:17])=[N:4][C:5]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([S:15]([CH3:16])=[O:20])=[CH:13][CH:14]=2)=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 176Acetic AcidHCID 178503248HCID 178503248, 화합물

생성물 1

HCID 178504606HCID 178504606, 화합물

실험 절차

11 g of 5-bromo-2-[4-(methylsulfanyl)phenylamino]pyrimidin-4-ol is suspended in 110 ml of glacial acetic acid. While being cooled with ice water, 4.6 ml of a 30% solution of hydrogen superoxide is added in drops. The mixture is stirred for 18 hours at room temperature and then suctioned off. The filter cake is washed twice with water and once with ethanol and dried at 60° C. in a vacuum. 8.75 g (75.7% of theory) of the product with a melting point of 240° C. (decomposition) is obtained.

후처리

  1. additionis added in drops
  2. washThe filter cake is washed twice with water and once with ethanol
  3. customdried at 60° C. in a vacuum
  4. custom8.75 g (75.7% of theory) of the product with a melting point of 240° C. (decomposition) is obtained

출처 및 근거

ORD 기록
ord-9a65733c52ab44cba3d14626c9308929
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07338958B2

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