反应详情

350 mg of 1-(cyclopropylsulfanyl)-4-nitrobenzene is dissolved in 5 ml of acetonitrile and mixed with 10 mg of iron(III)-chloride hexahydrate. After 10 minutes of stirring at room temperature, 450 mg of periodic acid is added thereto while being cooled. The mixture is stirred for 30 minutes at room temperature, cooled in an ice bath and mixed drop by drop with semi-saturated sodium disulfite solution. It is diluted with methylene chloride, washed with water, sodium bicarbonate solution and saturated sodium chloride solution, and concentrated by evaporation. After purification by flash chromatography, 270 mg of (RS)-1-(cyclopropylsulfinyl)-4-nitrobenzene is obtained.

1. temperaturewhile being cooled
2. stirringThe mixture is stirred for 30 minutes at room temperature
3. temperaturecooled in an ice bath
4. washwashed with water, sodium bicarbonate solution and saturated sodium chloride solution
5. concentrationconcentrated by evaporation
6. customAfter purification by flash chromatography