Sulfamethizole → HCID 178434115, compound

HRID 1391492Notes

Reaction equation

HRID 1391492 reaction equation
O[CH:2]=[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:12].[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:23][C:24]2[S:25][C:26]([CH3:29])=[N:27][N:28]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[CH3:29][C:26]1[S:25][C:24]([NH:23][S:20]([C:17]2[CH:18]=[CH:19][C:14]([NH:13]/[CH:2]=[C:3]3\[C:4](=[O:12])[NH:5][C:6]4[C:11]\3=[CH:10][CH:9]=[CH:8][CH:7]=4)=[CH:15][CH:16]=2)(=[O:22])=[O:21])=[N:28][N:27]=1

Participants

3

Reactant 2

HCID 5328SulfamethizoleHCID 1784187413-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178434115HCID 178434115, compound

Procedure

The title compound was prepared analogous to Example 5 from 3-(hydroxymethylene)-1,3-dihydro-2H-indol-2-one and 4-amino-N-(5-methyl[1,3,4]thiadiazol-2-yl)-benzenesulfonamide. 1H NMR (DMSO) 13.90 (bs, 1H); 10.84 (d, 1H); 10.58 (s, 1H); 8.62 (d, 1H); 7.81 (d, 2H); 7.60 (d, 1H); 7.55 (d, 2H); 7.12 (m, 1H); 6.95 (m, 1H); 7.84 (d, 1H); 2.48 (s, 3H). Electrospray MS 414 (MH+).

Sources & evidence

ORD record
ord-aa723887f28b41b082a1150483ba2799
Source dataset
uspto-grants-2008_03
Patent number
US07338966B2

Reaction notes

Loading…