Hydrazine → HCID 45078395, compound

HRID 1391548Notes

Reaction equation

HRID 1391548 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([N+:11]([O-])=O)=[CH:10][C:5]=2[N:4]=[C:3]1[NH2:14].NN>C(O)C>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([NH2:11])=[CH:10][C:5]=2[N:4]=[C:3]1[NH2:14]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 450786361-Methyl-5-nitro-1H-benzimidazol-2-amine

Product 1

HCID 45078395HCID 45078395, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 1-Methyl-5-nitro-1H-benzoimidazol-2-ylamine (0.19 g, 1 mmol) 10% Pd/C (50 mg) in ethanol (10 ml) was added hydrazine (0.5 ml) and the reaction was heated to 80° C. After TLC showed the starting material to be consumed, the reaction was cooled to rt and passed through a plug of celite. The filtrate was concentrated to give the title compound as an off-white solid. MS (ESI) m/z=163 [M+H]+.

Workup

  1. customto be consumed
  2. temperaturethe reaction was cooled to rt
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-32cab314128b474a870fd013758380bd
Source dataset
uspto-grants-2008_03
Patent number
US07338959B2

Reaction notes

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