1-(4-Aminophenyl)methanesulfonamide → HCID 10153034, compound

Participants

Reaction Steps

The title compound was prepared following the procedure of Example 1 with N2-benzyl-N5-(2-chloropyrimidin-4-yl)-N5,1-dimethyl-1H-benzimidazole-2,5-diamine (95 mg, 0.25 mmol) and (4-amino-phenyl)-methanesulfonamide (46 mg, 0.25 mmol) to give the desired product as a white solid (85 mg, 60%). 1H NMR (300 MHz, d6-DMSO+NaHCO3) δ 10.17 (brs, 2H), 9.53 (brs, 1H), 7.90 (d, J=6.6 Hz, 1H), 7.61 (d, J=8.4 Hz, 3H), 7.51 (d, J=7.5 Hz, 2H), 7.22-7.39 (m, 6H), 6.82 (s, 2H), 5.87 (d, J=6.0 Hz, 1H), 4.76 (d, J=5.7 Hz, 2H), 4.19 (s, 2H), 3.74 (s, 3H) 3.49 (s, 3H). MS (ESI) m/z=529 [M+H]+.

Provenance & Evidence