4-Amino-N-methylbenzeneethanesulfonamide → HCID 10129155, compound

Participants

Reaction Steps

The title compound was prepared following the procedure of Example 1 with N2-benzyl-N5-(2-chloropyrimidin-4-yl)-N5,1-dimethyl-1H-benzimidazole-2,5-diamine (95 mg, 0.25 mmol) and 2-(4-amino-phenyl)-ethanesulfonic acid methylamide (54 mg, 0.25 mmol) to give the desired product as a white solid (49 mg, 33%). 1H NMR (300 MHz, d6-DMSO+NaHCO3) δ 9.97 (br s, 1H), 9.34 (br s, 1H), 7.85 (d, J=6.6 Hz, 1H), 7.49-7.59 (m, 5H), 7.25-7.37 (m, 4H), 7.17 (d, J=8.1 Hz, 3H), 7.03 (q, J=5.4 Hz, 1H), 5.77 (d, J=6.6 Hz, 1H), 4.74 (d, J=5.1 Hz, 2H), 3.72 (s, 3H), 3.46 (s, 3H), 3.21-3.27 (m, 2H), 2.85-2.91 (m, 2H), 2.58 (d, J=4.8 Hz, 3H). MS (ESI) m/z=557 [M+H]+.

Provenance & Evidence