1-(4-Aminophenyl)methanesulfonamide → [4-(4-{[2-(4-Fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl]-methyl-amino}-pyrimidin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride

Participants

Reaction Steps

The title compound was prepared following the procedure of example two with N5-(2-chloro-pyrimidin-4-yl)-N2-(4-fluoro-benzyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine (99 mg, 0.25 mmol) and (4-amino-phenyl)-methanesulfonamide (46 mg, 0.25 mmol) as a white solid (50 mg, 34%). 1H NMR (300 MHz, d6-DMSO) δ9.16 (S, 1H), 7.75-7.78 (m, 3H), 7.38-7.46 (m, 3H), 7.08-7.24 (m, 6H), 6.84 (dd, J=8.2 and 1.6 Hz, 1H), 6.75 (br s, 2H), 5.61 (d, J=6.0 Hz, 1H), 4.57 (d, J=5.7 Hz, 2H), 4.15 (s, 2H), 3.56 (s, 3H), 3.43 (s, 3H). MS (ESI) m/z=547 [M+H]+.

Provenance & Evidence