4-[(methylsulfonyl)methyl]aniline(SALTDATA: FREE) → n5-[2-(4-Methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl]-n2-(4-methoxy-benzyl)-1,n5-dimethyl-1h-benzoimidazole-2,5-diamine hydrochloride

Participants

Reaction Steps

The title compound was prepared following the procedure of example two with N5-(2-chloro-pyrimidin-4-yl)-N2-(4-methoxy-benzyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine (82 mg, 0.20 mmol) and 4-[(methylsulfonyl)methyl]aniline (37 mg, 0.20 mmol) as a white solid (86 mg, 72%). 1H NMR (300 MHz, d6-DMSO) δ 9.21 (s, 1H), 7.76-7.81 (m, 3H), 7.29-7.34 (m, 3H), 7.21-7.25 (m, 3H), 7.09 (d, J=1.8 Hz, 1H), 6.82-6.90 (M, 3H), 5.64 (d, J=6.0 Hz, 1H), 4.52 (d, J=5.7 Hz, 2H), 4.35 (s, 2H), 3.72 (s, 3H), 3.56 (s, 3H), 3.43 (s, 3H), 2.85 (s, 3H). MS (ESI) m/z=558 [M+H]+.

Provenance & Evidence