4-[(methylsulfonyl)methyl]aniline(SALTDATA: FREE) → HCID 10153124, compound

HRID 1391581Notes

Reaction equation

HRID 1391581 reaction equation
[CH2:1]([NH:8][C:9]1[N:13]([CH2:14][CH3:15])[C:12]2[CH:16]=[CH:17][C:18]([N:20]([C:22]3[CH:27]=[CH:26][N:25]=[C:24]([Cl:28])[N:23]=3)[CH3:21])=[CH:19][C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:29][S:30]([CH2:33][C:34]1[CH:40]=[CH:39][C:37]([NH2:38])=[CH:36][CH:35]=1)(=[O:32])=[O:31]>>[ClH:28].[CH2:1]([NH:8][C:9]1[N:13]([CH2:14][CH3:15])[C:12]2[CH:16]=[CH:17][C:18]([N:20]([C:22]3[CH:27]=[CH:26][N:25]=[C:24]([NH:38][C:37]4[CH:39]=[CH:40][C:34]([CH2:33][S:30]([CH3:29])(=[O:32])=[O:31])=[CH:35][CH:36]=4)[N:23]=3)[CH3:21])=[CH:19][C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 128439644-[(methylsulfonyl)methyl]aniline(SALTDATA: FREE)HCID 59674155HCID 59674155, compound

Product 1

HCID 10153124HCID 10153124, compound

Procedure

The title compound was prepared following the procedure of example two with N2-Benzyl-N5-(2-chloro-pyrimidin-4-yl)-1-ethyl-N5-methyl-1H-benzoimidazole-2,5-diamine (98 mg, 0.25 mmol) and 4-[(methylsulfonyl)methyl]aniline (46 mg, 0.25 mmol) as a white solid (65 mg, 45%). 1H NMR (300 MHz, d6-DMSO+NaHCO3) δ 9.53 (s, 1H), 7.75 (m, 3H), 7.19-7.40 (M, 9H), 7.10 (s, 1H), 6.87 (m, 1H), 5.66 (m, 1H), 4.60 (m, 2H), 4.32 (s, 2H), 4.11 (m, 2H), 6.41 (s, 3H), 2.83 (s, 3H), 1.24 (M, 3H).

Sources & evidence

ORD record
ord-6ceba40adba14de28c8c545701d6ac34
Source dataset
uspto-grants-2008_03
Patent number
US07338959B2

Reaction notes

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