5-Amino-2-methylbenzenesulfonamide → HCID 10239976, compound

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Reaction Steps

The title compound was prepared following the procedure of example one with N5-(2-chloro-pyrimidin-4-yl)-N2-(2-fluoro-benzyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine (60 mg, 0.15 mmol) and 5-amino-2-methyl-benzenesulfonamide (28 mg, 0.15 mmol) as a white solid (69 mg, 79%). 1H NMR (300 MHz, d6-DMSO+NaHCO3) δ 9.71 (s, 1H), 8.55 (s, 1H), 7.81 (d, J=6.0 Hz, 1H), 7.68 (dd, J=8.1 and 1.8 Hz, 1H), 7.44-7.54 (m, 2H), 7.16-7.36 (m, 7H), 7.07 (d, J=8.4 Hz, 1H), 5.68 (d, J=6.3 Hz, 1H), 4.73 (d, J=5.1 Hz, 2H), 3.67 (s, 3H), 3.47 (s, 3H), 2.50 (s, 3H). MS (ESI) m/z=547 [M+H]+.

Provenance & Evidence