5-Amino-2-methylbenzenesulfonamide → 2-Methyl-5-(4-{methyl-[1-methyl-2-(1-phenyl-ethylamino)-1H-benzoimidazol-5-yl]-amino}-pyrimidin-2-ylamino)-benzenesulfonamide hydrochloride

Participants

Reaction Steps

The title compound was prepared following the procedure of example one with N5-(2-Chloro-pyrimidin-4-yl)-1,N5-dimethyl-N2-(1-phenyl-ethyl)-1H-benzoimidazole-2,5-diamine (98 mg, 0.25 mmol) and 5-amino-2-methyl-benzenesulfonamide (46 mg, 0.25 mmol) as a white solid (90 mg, 63%). 1H NMR (300 MHz, d6-DMSO+NaHCO3) δ 9.85 (br s, 2H), 8.52 (s, 1H), 7.83 (d, J=6.3 Hz, 1H), 7.65-7.68 (dd, J=8.1 and 1.8 Hz, 1H), 7.51-7.57 (m, 3H), 7.34-7.39 (m, 2H), 7.25-7.30 (m, 4H), 7.15-7.22 (m, 2H), 5.70 (d, J=6.3 Hz, 1H), 5.22 (m, 1H), 3.74 (s, 3H), 3.47 (s, 3H), 2.51 (s, 3H), 1.63 (d, J=6.6 Hz, 3H). MS (ESI) m/z=543 [M+H]+.

Provenance & Evidence