反应详情

The title compound was prepared following the procedure of example two with N5-(2-Chloro-pyrimidin-4-yl)-1,N5-dimethyl-N2-(1-phenyl-ethyl)-1H-benzoimidazole-2,5-diamine (98 mg, 0.25 mmol) and 4-[(methylsulfonyl)methyl]aniline (46 mg, 0.25 mmol) as a white solid (66 mg, 46%). 1H NMR (400 MHz, d6-DMSO) δ 9.18 (s, 1H), 7.72-7.77 (M, 3H), 7.42 (d, J=7.6 Hz, 2H), 7.16-7.21 (m, 4H), 7.10 (d, J=8.0 Hz, 1H), 7.02 (d, J=2.0 Hz, 1H), 6.79 (dd, J=8.4 and 2.0 Hz, 1H), 5.58 (d, J=5.6 Hz, 1H), 5.12 (m, 1H), 4.31 (s, 2H), 3.58 (s, 3H), 3.38 (s, 3H), 2.82 (s, 3H), 1.50 (d, J=6.8 Hz, 3H). MS (ESI) m/z=542 [M+H]+.