1-(4-Aminophenyl)methanesulfonamide → [4-(4-{Methyl-[1-methyl-2-(1-phenyl-ethylamino)-1H-benzoimidazol-5-yl]-amino}-pyrimidin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride

Participants

Reaction Steps

The title compound was prepared following the procedure of example two with N5-(2-Chloro-pyrimidin-4-yl)-1,N5-dimethyl-N2-(1-phenyl-ethyl)-1H-benzoimidazole-2,5-diamine (98 mg, 0.25 mmol) and (4-amino-phenyl)-methanesulfonamide (46 mg, 0.25 mmol) as a white solid (90 mg, 62%). 1H NMR (400 MHz, d6-DMSO) δ 9.13 (s, 1H), 7.71-7.75 (m, 3H), 7.42 (d, J=7.6 Hz, 2H), 7.26-7.30 (M, 2H), 7.16-7.19 (m, 4H), 7.11 (d, J=8.0 Hz, 1H), 7.02 (d, J=2.0 Hz, 1H), 6.79 (dd, J=8.4 and 2.0 Hz, 1H), 6.73 (s, 2H), 5.56 (d, J=6.0 Hz, 1H), 5.12 (m, 1H), 4.12 (s, 2H), 3.58 (s, 3H), 3.38 (s, 3H), 1.50 (d, J=7.2 Hz, 3H). MS (ESI) m/z=543 [M+H]+.

Provenance & Evidence