4-Amino-N-methylbenzeneethanesulfonamide → HCID 10128803, compound

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Reaction Steps

The title compound was prepared following the procedure of example 1 with N5-(2-chloropyrimidin-4-yl)-N2-isopropyl-N5,1-dimethyl-1H-benzimidazole-2,5-diamine (83 mg, 0.25 mmol) and 2-(4-amino-phenyl)-ethanesulfonic acid methylamide (54 mg, 0.25 mmol) as a white solid (71 mg, 52%). 1H NMR (300 MHz, d6-DMSO) δ 9.05 (s, 1H), 7.68-7.76 (M, 3H), 7.19 (d, J=8.4 Hz, 1H), 7.08-7.13 (M, 3H), 6.96 (q, J=5.1 Hz, 1H), 6.81 (dd, J=8.1 and 1.8 Hz, 1H), 6.53 (d, J=6.9 Hz, 1H), 5.60 (d, J=5.7 Hz, 1H), 4.04 (m, 1H), 3.51 (s, 3H), 3.42 (s, 3H), 3.21-3.30 (m, 2H), 2.83-2.88 (m, 2H), 2.59 (d, J=5.1 Hz, 3H), 1.23 (d, J=6.6 Hz, 6H) ppm. MS (ESI) m/z=509 [M+H]+.

Provenance & Evidence