3-(Methanesulfonylmethyl)aniline → HCID 10289333, compound

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Reaction Steps

The title compound was prepared following the procedure of example 1 with N5-(2-chloropyrimidin-4-yl)-N2-isopropyl-N5,1-dimethyl-1H-benzimidazole-2,5-diamine (83 mg, 0.25 mmol) and 3-Methanesulfonylmethyl-phenylamine (46 mg, 0.25 mmol) as a white solid (69 mg, 53%). 1H NMR (300 MHz, d6-DMSO) δ 9.20 (s, 1H), 7.90 (s, 1H), 7.77 (d, J=6.0 Hz, 1H), 7.69 (d, J=8.1 Hz, 1H), 7.18-7.25 (m, 2H), 7.09 (d, J=1.8 Hz, 1H), 6.91 (d, J=7.5 Hz, 1H), 6.82 (dd, J=8.1 and 1.8 Hz, 1H), 6.49 (d, J=7.5 Hz, 1H), 5.64 (d, J=6.0 Hz, 1H), 4.34 (s, 2H), 4.03 (m, 1H), 3.51 (s, 3H), 3.43 (s, 3H), 2.89 (s, 3H), 1.24 (d, J=6.6 Hz, 6H) ppm. MS (ESI) m/z=480 [M+H]+.

Provenance & Evidence