1-(4-Aminophenyl)methanesulfonamide → HCID 69267199, compound

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Reaction Steps

The title compound was prepared following the procedure of Example 1 with N5-(2-Chloro-pyrimidin-4-yl)-1-ethyl-N2,N5-dimethyl-1H-benzoimidazole-2,5-diamine (79 mg, 0.25 mmol) and (4-amino-phenyl)-methanesulfonamide (46 mg, 0.25 mmol) as a white solid (110 mg, 88%). 1H NMR (300 MHz, d6-DMSO) δ 9.24 (s, 1H), 7.81 (d, J=6.0 Hz, 1H), 7.74 (m, 3H), 7.36 (d, J=8.1 Hz, 1H), 7.17-7.20 (M, 3H), 6.96 (d, J=8.4 Hz, 1H), 6.78 (s, 2H), 5.70 (d, J=6.0 Hz, 1H), 4.09-4.16 (m, 4H), 3.45 (s, 3H), 2.97 (d, J=4.5 Hz, 3H), 1.24 (t, J=6.9 Hz, 3H) ppm. MS (ESI) m/z=467 [M+H]+.

Provenance & Evidence