3-(Methanesulfonylmethyl)aniline → HCID 131726798, compound

HRID 1391631Notes

Reaction equation

HRID 1391631 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([N:10]([C:17]2[N:21]([CH3:22])[C:20]3[CH:23]=[CH:24][C:25]([N:27]([C:29]4[CH:34]=[CH:33][N:32]=[C:31](Cl)[N:30]=4)[CH3:28])=[CH:26][C:19]=3[N:18]=2)C(=O)C(C)(C)C)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:36][S:37]([CH2:40][C:41]1[CH:42]=[C:43]([CH:45]=[CH:46][CH:47]=1)[NH2:44])(=[O:39])=[O:38]>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:17]2[N:21]([CH3:22])[C:20]3[CH:23]=[CH:24][C:25]([N:27]([C:29]4[CH:34]=[CH:33][N:32]=[C:31]([NH:44][C:43]5[CH:45]=[CH:46][CH:47]=[C:41]([CH2:40][S:37]([CH3:36])(=[O:39])=[O:38])[CH:42]=5)[N:30]=4)[CH3:28])=[CH:26][C:19]=3[N:18]=2)[CH:6]=1)([CH3:3])([CH3:2])[CH3:4]

Participants

3

Reactant 2

HCID 219563393-(Methanesulfonylmethyl)anilineHCID 87758804HCID 87758804, compound

Product 1

HCID 131726798HCID 131726798, compound

Procedure

The title compound was prepared following the procedure of Example 134 with N-(5-tert-Butyl-isoxazol-3-yl)-N-{5-[(2-chloro-pyrimidin-4-yl)-methyl-amino]-1-methyl-1H benzoimidazole-2-yl}-2,2-dimethyl-propionamide (23 mg, 0.045 mmol) and 3-[(methylsulfonyl)methyl]aniline (10 mg, 0.139 mmol) to afford a white solid (5 mg, 0.01 mmol). MS (ESI) m/z=561 [M+H]+.

Sources & evidence

ORD record
ord-9ced2deaca464e1886250a98267b7114
Source dataset
uspto-grants-2008_03
Patent number
US07338959B2

Reaction notes

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