Sodium borohydride → 1-[4'-(Trifluoromethyl)-4-biphenylyl]-1-pentanol

Participants

Reaction Steps

To a solution of 1-[4′-(trifluoromethyl)-4-biphenylyl]-1-pentanone (500 mg, 1.63 mmol) in THF (16 mL) and water (8 mL) under nitrogen at 0° C. (ice/water bath) was added sodium borohydride (74 mg, 1.96 mmol) portion-wise. After stirring the mixture for 1 hour at rt, the reaction was diluted with water (30 mL) and extracted into EtOAc (3×30 mL). The combined organic extract was separated, dried (MgSO4) and reduced under vacuum to afford the title compound as a colourless gum (490 mg).

Provenance & Evidence