HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-(Trifluoromethyl)phenyl)picolinaldehyde → 3-Methyl-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-butanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-(Trifluoromethyl)phenyl)picolinaldehyde | HCID 24730089 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | HCID 178418816 | HCID 178418816 | — |
| Product | 3-Methyl-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-butanol | HCID 58629813 | — |
Reaction Steps
Prepared from 6-[4-(trifluoromethyl)phenyl]-2-pyridinecarbaldehyde (500 mg, 1.99 mmol) in Et2O (20 mL) and isobutylmagnesium bromide (1.1 mL of a 2M solution in Et2O, 2.2 mmol) according to the procedure used for the preparation of Intermediate 47 to give, after purification by SPE (silica, 10 g cartridge) eluting with cyclohexane:EtOAc (gradient 99:1 to 4:1) the title compound as a white crystalline solid (215 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07338960B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-5192f9156d58497c9a00d048bcf09144 |
| Source note | uspto-grants-2008_03 |