Sodium borohydride → HCID 58629904, compound

Participants

Reaction Steps

To a solution of 1-(6-bromo-2-pyridinyl)-3-(methyloxy)-1-propanone (547 mg, 2.24 mmol) in anhydrous MeOH (15 mL) under nitrogen at 0° C. was treated portion-wise with sodium borohydride (127 mg, 3.36 mmol) over 10 min. The resulting solution was stirred under nitrogen and gradually allowed to warm to room temperature over 2 h. The reaction mixture was then diluted with aqueous HCl (0.5M, 20 mL) and the resulting mixture extracted with EtOAc (2×50 mL). The combined organic layer was dried (MgSO4) and reduced under vacuum to afford the title compound as an off-white gum (551 mg).

Provenance & Evidence