HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-hydroxybenzaldehyde → 2-Chloro-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-hydroxybenzaldehyde | HCID 185363 | — |
| Reactant | (1R)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol | HCID 69207951 | — |
| Product | 2-Chloro-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]benzaldehyde | HCID 58629849 | 35% |
Reaction Steps
Prepared according to the procedure used to prepare Intermediate 103 starting from (1R)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol (202 mg, 0.65 mmol) and 2-chloro-4-hydroxybenzaldehyde (140, 0.89 mmol) to afford the title compound (102 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07338960B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-59907b73bcad46d1aca11c5beb3ed79f |
| Source note | uspto-grants-2008_03 |