HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-hydroxybenzaldehyde → 3-Chloro-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-hydroxybenzaldehyde | HCID 17022 | — |
| Reactant | (1R)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol | HCID 69207951 | — |
| Product | 3-Chloro-4-[((1S)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}pentyl)oxy]benzaldehyde | HCID 58629834 | 19.7% |
Reaction Steps
Prepared according to the procedure used to prepare Intermediate 103 from (1R)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}-1-pentanol (208 mg, 0.67 mmol) and 3-chloro-4-hydroxybenzaldehyde (141, 0.90 mmol) to afford the title compound (59 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07338960B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-7401ff7f4a914435964ef62950d66a4b |
| Source note | uspto-grants-2008_03 |