Tetrabutylammonium Fluoride → HCID 58629884, compound

Participants

Reaction Steps

To a stirred solution of ethyl ({4-[(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]-2-methylphenyl}oxy)acetate (208 mg, 0.352 mmol) in THF (3.5 mL) was added TBAF (1M in THF, 0.458 mL) dropwise over 1 min. The resulting solution was then stirred at ambient temperature for 18 h. The mixture was then reduced under vacuum and the residue purified by SPE (silica, 10 g cartridge) eluting with cyclohexane:EtOAc (gradient 15:1 to 2:1) to afford the title compound (89 mg).

Provenance & Evidence