Triphenylphosphine → HCID 58629900, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of ethyl [(4-hydroxy-2-methylphenyl)oxy]acetate (664 mg, 3.16 mmol), 4-{6-[(1R)-2-(ethyloxy)-1-hydroxyethyl]-2-pyridinyl}benzonitrile (719 mg, 2.68 mmol) and triphenylphosphine (857 mg, 3.27 mmol) in dry DCM (35 mL) was cooled to 0° C. under nitrogen. DIAD (633 μL, 3.21 mmol) was added dropwise over 10 min, and the reaction mixture stirred at 0° C. for a further 2 h. DCM (120 mL) was added to the reaction mixture, washed with aq 1M NaOH (50 mL) and water (100 mL), dried (Na2SO4) and evaporated to give a yellow oil. Purification by Biotage™ chromatography (silica, 90 g cartridge) eluting with cyclohexane:EtOAc (8:1) afforded the title compound as a colourless oil (765 mg).

Provenance & Evidence