反应详情

A suspension of [(2-methyl-4-{2-[4′-(trifluoromethyl)-3-biphenylyl]ethenyl}phenyl)oxy]acetic acid (90 mg, 0.22 mmol) in EtOH (10 mL) was added to Pd/C (Degussa type E101 NE/N) (10 mg, 11 wt %) and the resulting mixture stirred under an atmosphere of hydrogen for 6 hours. The mixture was then filtered through celite J2 washing with copious amounts of EtOH and the filtrate reduced under vacuum to give a sticky solid (100 mg) which was purified by mass directed auto-prep HPLC to give the title compound as a fluffy white solid (25 mg).

1. filtrationThe mixture was then filtered through celite
2. washJ2 washing with copious amounts of EtOH