Hydrochloric Acid → HCID 10048485, compound

Participants

Reaction Steps

A solution of ethyl ({2-methyl-4-[({6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}methyl)thio]phenyl}oxy)acetate (367 mg, 0.80 mmol) in THF (5 mL) was treated with aqueous NaOH (2M, 5 mL) and the resulting solution stirred at rt for 4 hours. The mixture was poured into a mixture of aqueous HCl (2M) and EtOAc and the layers separated. The organic layer was then washed with water and brine, dried MgSO4, filtered and then reduced under vacuum. Purification by mass-directed auto-prep HPLC afforded the title compound as an oil.

Provenance & Evidence