Sodium Hydroxide → HCID 11744278, compound

Participants

Reaction Steps

A mixture of ethyl {[2-methyl-4-({1-[4′-(trifluoromethyl)-3-biphenylyl]ethyl}thio)phenyl]oxy}acetate (235 mg, 0.50 mmol) in dioxane (6 mL) was treated with aqueous NaOH (0.5N, 2.0 mL, 1.00 mmol) and the mixture heated at reflux for 1 hour. The resulting mixture was then cooled and treated with Dowex 50WX2 (pre-washed with dioxan), filtered and washed with more dioxan and reduced to give the title compound as a colourless gum (220 mg).

Provenance & Evidence