Hydrochloric Acid → HCID 10096338, compound

Participants

Reaction Steps

Ethyl {[2-methyl-4-({1-[4′-(trifluoromethyl)-3-biphenylyl]pentyl}oxy)phenyl]oxy}acetate (138 mg, 0.28 mmol) was dissolved in THF (1.5 mL), water (0.5 mL) and aqueous NaOH (2M, 0.52 mL, 1.04 mmol) and the mixture stirred at 70° C. for 2 hours, cooled to rt and acidified to pH4 with aqueous hydrochloric acid (2M). The mixture was then partitioned between EtOAc and water, the layers separated and the organic layer washed with brine, dried (Na2SO4) and concentrated to give the title compound as a colourless gum (130 mg).

Provenance & Evidence