Hydrochloric Acid → HCID 10480650, compound

Participants

Reaction Steps

To a solution of ethyl {[2-methyl-4-({(1R)-1-[4′-(trifluoromethyl)-4-biphenylyl]pentyl}thio)phenyl]oxy}acetate (10 mg, 0.02 mmol) in THF (1 mL) and MeOH (1 mL) was added aqueous NaOH (2M, 1 mL) and the resulting mixture agitated for 1.5 hours at rt. The mixture was then reduced under vacuum, acidified with aqueous HCl (2M), extracted with DCM (2 mL) and reduced to afford the title compound as colourless oil (9 mg).

Provenance & Evidence