Hydrochloric Acid → HCID 58629918, compound

Participants

Reaction Steps

Ethyl [(4-{[(1S)-1-[6-(4-cyanophenyl)-2-pyridinyl]-2-(ethyloxy)ethyl]oxy}-2-methylphenyl)oxy]acetate (0.886 g) was dissolved in THF (8.8 mL). Water (8.8 mL) and aq 2M NaOH (1.8 mL) were added and the mixture stirred at ambient temperature for 30 mins. The reaction mixture was acidified to pH 1 by the addition of aq 2M HCl and extracted with EtOAc (2×10 mL). The organic extracts were washed with brine (20 mL), dried (Na2SO4) and evaporated to give the title compound as a white foam (729 mg).

Provenance & Evidence