Thionyl Chloride → 5-Chloro-1-benzofuran-2-carbonyl chloride

HRID 1391831Notes

Reaction equation

HRID 1391831 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10](O)=[O:11])=[CH:7][C:6]=2[CH:13]=1.S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([Cl:16])=[O:11])=[CH:7][C:6]=2[CH:13]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 9378385-Chloro-1-benzofuran-2-carboxylic acid

Product 1

HCID 337407645-Chloro-1-benzofuran-2-carbonyl chloride

Procedure

A solution of 5-chloro-1-benzofuran-2-carboxylic acid (827 mg, 42 mmol) in thionyl chloride (4 mL) was refluxed over night. The solvent was removed in vacuo to give the 5-chloro-1-benzofuran-2-carbonyl chloride in quantitative yield.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1371deb182bc4d92a6767f85cf58b3b7
Source dataset
uspto-grants-2008_03
Patent number
US07339059B2

Reaction notes

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