HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-chlorobenzoic acid → HCID 178518014, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-chlorobenzoic acid | HCID 66646 | — |
| Reactant | Formamidine acetate | HCID 160693 | — |
| Reactant | 1-Ethoxyethanol | HCID 10129898 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 178518014 | HCID 178518014 | 130.2% |
Reaction Steps
2-Amino-4-chloro-benzoic acid (1.00 g, 11.7 mmol, 1.0 eq.), formamidine acetate (3.64 mL, 35.0 mmol, 3 eq.), and ethoxyethanol (20 mL) were refluxed under nitrogen overnight. Cooled to rt. Added 25 mL of diethyl ether. Solids precipitated. Filtered off solids. Pumped under high vacuum to give 2.75 g of white solids as product. LCMS detects (M+H)+=181.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07338947B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-0a96dd822490415680abd16233abcd5b |
| Source note | uspto-grants-2008_03 |