Formic Acid → HCID 178517998, compound

HRID 1391898Notes

Reaction equation

HRID 1391898 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH:15](O)=O>O>[F:14][C:11]([F:12])([F:13])[C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:15][N:6]=[C:4]2[OH:5]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 210882212-Amino-5-(trifluoromethyl)benzamide

Product 1

HCID 178517998HCID 178517998, compoundYield 49.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Amino-5-trifluoromethyl-benzamide (ButtPark) (1.00 g, 4.90 mmol, 1 eq.) and formic acid (3.30 mL, 87.2 mmol, 17.8 eq.) were refluxed for 2.5 hours. Cooled to rt then added water (10 mL). Stirred 15 minutes then filtered off solids which were present. The solids were dried at 110° C. for 3 hours to give 520 mg of white solids as product. LCMS detects (M+H)+=215.

Workup

  1. filtrationthen filtered off solids which
  2. customThe solids were dried at 110° C. for 3 hours

Sources & evidence

ORD record
ord-e389fa3038fa47878012747c97bf1476
Source dataset
uspto-grants-2008_03
Patent number
US07338947B2

Reaction notes

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