HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamidine acetate → HCID 178440588, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamidine acetate | HCID 160693 | — |
| Reactant | Methyl 3-amino-5-tert-butylthiophene-2-carboxylate | HCID 2777503 | — |
| Solvent | Glycol monoethyl ether | HCID 8076 | — |
| Product | HCID 178440588 | HCID 178440588 | 99.3% |
Reaction Steps
3-Amino-5-tert-butyl-thiophene-2-carboxylic acid methyl ester (1.00 g, 4.69 mmol, 1 eq.), formamidine acetate (1.46 g, 4.69 mmol, 3 eq.) and 2-ethoxyethanol (10 mL) were refluxed under nitrogen for 4 hours. Purified over silica gel in 3:1 to 1:1 Hexanes/ethyl acetate to 100% ethyl acetate to obtain 970 mg of yellow solids as product. LCMS detects (M+H)+=209.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07338947B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-51cc239e646c4916a63b657425779cd3 |
| Source note | uspto-grants-2008_03 |