L-Serine → L-Aspartic Acid

HRID 1391984Notes

Reaction equation

HRID 1391984 reaction equation
[OH-].[Ca+2].[OH-].[NH2:4][C@H:5]([C:9]([OH:11])=[O:10])[C@@H:6]([CH3:8])[OH:7].N[C@H]([C:16]([OH:18])=[O:17])CO.[NH2:19][C@H:20]([C:25]([OH:27])=[O:26])[CH2:21][C:22]([OH:24])=[O:23]>O>[NH2:4][C@H:5]([C:9]([OH:11])=[O:10])[CH2:6][CH2:8][C:16](=[O:17])[OH:18].[NH2:4][C@H:5]([C:9]([OH:11])=[O:10])[C@@H:6]([CH3:8])[OH:7].[NH2:19][C@H:20]([C:25]([OH:27])=[O:26])[CH2:21][C:22](=[O:23])[OH:24]

Participants

8

Reactant 4

HCID 5951L-SerineHCID 5960L-Aspartic AcidHCID 6288L-ThreonineHCID 6093208Calcium Hydroxide

Product 3

HCID 5960L-Aspartic AcidHCID 6288L-ThreonineHCID 33032L-Glutamic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.2482 g of glutamine acid were dissolved in 200 mL of water by stirring after which, 2.1407 g of calcium hydroxide were added and the solution further stirred for about 20 minutes until the pH of reaction solution was about 10.44. 3.4476 g of threonine were then added and the reaction solution stirred for another 30 minutes during which time the solution pH of solution dropped to and stabilized at 9.08. Next, 3.0383 g of serine were added and the reaction solution stirred for 20 minutes after which time it was determined that the pH of the reaction solution dropped to 8.72. Finally, 3.4630 g of aspartic acid were added to the reaction solution which was then stirred for a further 190 minutes. The pH of the final clear reaction solution was pH 7.00. The final reaction solution was filtered, then evaporated in the rotary evaporator after which, the amino acid chelate product was dried to solids under vacuum as previously described. This method produced a pure amino acid chelate with a metal to amino acid ratio of about 1:4 (Ca:Glu:Thr:Ser:Asp).

Workup

  1. additionwere added
  2. stirringthe reaction solution stirred for another 30 minutes during which time the solution pH of solution
  3. additiondropped to and
  4. stirringthe reaction solution stirred for 20 minutes after which time it
  5. additiondropped to 8.72
  6. stirringwas then stirred for a further 190 minutes
  7. customThe final reaction solution
  8. filtrationwas filtered
  9. customevaporated in the rotary evaporator after which
  10. dry with materialthe amino acid chelate product was dried to solids under vacuum

Sources & evidence

ORD record
ord-74b16ba5b43a4681bb177ea10abb4cc5
Source dataset
uspto-grants-2008_03
Patent number
US07341708B1

Reaction notes

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