Acetophenone → 1-Phenylethanol, (R)-

HRID 1392003Notes

Reaction equation

HRID 1392003 reaction equation
[C:1]1([C@@H:7]([OH:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(C1C=CC=CC=1)(=O)C>>[C:1]1([C@H:7]([OH:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7410AcetophenoneHCID 4431351-Phenylethanol, (S)-

Product 1

HCID 6375161-Phenylethanol, (R)-

Procedure

Analysis showed that (S)-phenylethanol was fully oxidised after 2 h and a corresponding amount of the oxidation product acetophenone could be found by gas chromatography. (R)-phenylethanol remained untouched so an ee value of >99% is obtained for this enantiomer.

Sources & evidence

ORD record
ord-40c6a5042359439986031c9b8bfde3fb
Source dataset
uspto-grants-2008_03
Patent number
US07341859B2

Reaction notes

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