HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiirane → HCID 86609047, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiirane | HCID 9865 | — |
| Reactant | 4-(piperazin-1-yl)-1H-indole | HCID 594590 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86609047 | HCID 86609047 | 43.4% |
Reaction Steps
1-(1H-Indol-4-yl)piperazine (3.9 g) and thiirane (1.75 g) was dissolved in DMF (200 mL) and refluxed for 1 h. The mixture was evaporated and re-dissolved in TBF, dried with MgSO4, filtered and evaporated to give the an oil which was subjected to purification by column chromatography (silica gel; ethyl acetate and heptane) giving the title compound as an oil (2,2 g). MS m/z (%): 261 (MH+, 100%), 202 (100%), 159 (23%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07342015B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-d94be4617f2644139e61516bde9a76e5 |
| Source note | uspto-grants-2008_03 |