(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 11744123, compound

Participants

Reaction Steps

Using a procedure similar to that described in example 3, except using (3R,7R)-3-amino-1-methyl-7-phenylazepan-2-one (3f) (60 mg) to couple with N-[(3,5-difluorophenyl)acetyl]-L-alanine (1e) (67 mg), the title compound was obtained as a white solid (100 mg, 84%). 1H NMR (300 MHz, CDCl3) δ 1.39 (d, 3H), 1.57 (m, 1H), 1.94 (m, 3H), 2.14 (m, 2H), 2.51 (s, 3H), 3.56 (s, 2H), 4.51-4.56 (m, 1H), 4.92-4.95 (m, 2H), 6.24 (bd, 1H), 6.70-6.75 (m, 1H), 6.83-6.85 (bd, 2H), 7.28-7.39 (m, 6H). MS APCI, m/z=444 (M+1). LC/MS 2.33 min., Method A.

Provenance & Evidence