Cyclopropylamine → HCID 10728910, compound

HRID 1392115Notes

Reaction equation

HRID 1392115 reaction equation
Cl[C:2]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.[CH:15]1([NH2:18])[CH2:17][CH2:16]1>C(O)C>[CH:15]1([NH:18][C:2]2[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[N:8]=[C:7]3[C:3]=2[NH:4][CH:5]=[N:6]3)[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 60539116-chloro-2-(trifluoromethyl)-7H-purine

Product 1

HCID 10728910HCID 10728910, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 12 g (54 mmol) of 6-chloro-2-trifluoromethylpurine, 30 g (540 mmol) of cyclopropylamine and 250 mL of ethanol was stirred at room temperature for 4.5 days leaving a white solid. The mixture was concentrated in vacuo to dryness, 215 mL of H2O was added and the mixture was stirred for 1 hour. The product was collected by filtration and after drying (vacuum oven, 50° C., 5 hours) 8.1 g of product was obtained, 62% yield. M.P. 260° C. (dec.); 1H NMR (CD3OD) δ 8.18 (s, 1H), 3.30 (bs, 1H), 0.904 (m, 2H), 0.67 (m, 2H).

Workup

  1. customleaving a white solid
  2. concentrationThe mixture was concentrated in vacuo to dryness, 215 mL of H2O
  3. additionwas added
  4. stirringthe mixture was stirred for 1 hour
  5. filtrationThe product was collected by filtration
  6. dry with materialafter drying (vacuum oven, 50° C., 5 hours) 8.1 g of product
  7. customwas obtained

Sources & evidence

ORD record
ord-3e2648152d5e4331a5702bb13b96ad6c
Source dataset
uspto-grants-2008_03
Patent number
US07342021B2

Reaction notes

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