Potassium Hydroxide → HCID 9816790, compound

Participants

Reaction Steps

760 mg 2,7-dimethyl-imidazo[1,2-a]pyridine-3-carboxylic acid (4-methyl-pyridin-2-yl)-amide were added to a suspension of 160 mg lithium aluminium hydride in 12 ml tetrahydrofuran at room temperature. The mixture was then heated under reflux for 2.5 hours. After addition of an aqueous KOH solution, the resulting suspension was heated under reflux again for 15 minutes. After filtration, distillation of the solvent and purification by column chromatography, the product was obtained with a yield of 25%.

Provenance & Evidence