1,2-Dichloroethane → HCID 10174641, compound

Participants

Reaction Conditions

Reaction Steps

To 5,6-Bis-(4-bromophenyl)-pyrazine-2-carboxylic acid (108 mg, 0.25 mmol) from Preparation A, step (b), DMAP (0.025 mmol, in 500 μl DCM), 1-aminopiperidine (0.25 mmol, in 1100 μl DCM), EDC (0.27 mmol, in 1100 μl DCM and cooled to 8° C.) were added. The reaction mixture was stirred at 25° C. for 20 h, then washed with saturated NaHCO3 solution, dried (MgSO4), filtered and evaporated. Semipreparatory HPLC (0.01% TEA in the buffered phase) gave the subtitle compound (6.7 mg, 5.4%).

Provenance & Evidence