Sodium Hydroxide → HCID 22479213, compound

HRID 1392164Notes

Reaction equation

HRID 1392164 reaction equation
[OH-].[Na+].C[O:4][C:5]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:40]=[CH:39][C:18]([CH2:19][C:20]23[C:28](=[O:29])[N:27]([C:30]4[CH:35]=[C:34]([Cl:36])[CH:33]=[C:32]([Cl:37])[CH:31]=4)[C:26](=[O:38])[N:25]2[CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:17][CH:16]=1)=[O:6]>CO.O>[C:5]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:16]=[CH:17][C:18]([CH2:19][C:20]23[C:28](=[O:29])[N:27]([C:30]4[CH:31]=[C:32]([Cl:37])[CH:33]=[C:34]([Cl:36])[CH:35]=4)[C:26](=[O:38])[N:25]2[CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:39][CH:40]=1)([OH:6])=[O:4]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 22479244HCID 22479244, compound

Product 1

HCID 22479213HCID 22479213, compoundYield 101.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

An aqueous solution of NaOH (2 mL; 0.5 N) was added to a solution of 6-[4-[2-(2-methoxycarbonylethyl)phenyl]benzyl]-8-(3,5-dichlorophenyl)-1,8-diazabicyclo[4.3.0]nonane-7,9-dione (0.11 g) in MeOH (7 mL) and the mixture was stirred for 18 hours. The reaction mixture was acidified, diluted with water and extracted with EtOAc. The extract was washed with water, brine, dried (MgSO4), filtered, and concentrated to give the titled compound (0.109 g). MS (m/z) 559 (M++Na).

Workup

  1. extractionextracted with EtOAc
  2. washThe extract was washed with water, brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-5030e748ff01459a82c6bbedf4eeeb84
Source dataset
uspto-grants-2008_03
Patent number
US07342012B2

Reaction notes

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