反应详情

To a solution of (5R,7S)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-7-azido-1,3-diazabicyclo[3.3.0]octane-2,4-dione (0.83 g) in acetic acid (20 mL) was added zinc powder (0.90 g). After 1 hour at room temperature, the mixture was concentrated. The residue was suspended in satd. NaHCO3 and EtOAc. The mixture was filtered and the organic layer was collected, washed with brine, dried (Na2SO4), filtered and concentrated. Purification of the residue by chromatography (silica gel: CH2Cl2: Chromatotron) afforded the titled compound (0.42 g). MS (m/z) 468 (MH+). mp 64.4° C.

1. concentrationthe mixture was concentrated
2. filtrationThe mixture was filtered
3. customthe organic layer was collected
4. washwashed with brine
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated
8. customPurification of the residue by chromatography (silica gel: CH2Cl2: Chromatotron)