Sodium Chloride → HCID 23079426, compound

Participants

Reaction Conditions

Reaction Steps

To 2 g of N,N-dimethylformamide, 0.257 g of 5-chloro-3-(4-methylbenzyl)thio-1,2,4-thiadiazole and 0.145 g of 2,2-dimethyl-1,3-dioxolane-4-methanol were dissolved, and added 48 mg of sodium hydride (60% in oil) at about 0° C., followed by stirring at about 0° C. for 30 minutes and at room temperature for 4 hours. Then, the reaction mixture was added to saturated sodium chloride aqueous solution, and extracted with tert-butylmethylether. The organic layer was concentrated, and the residue obtaind was subjected to silica gel column chromatography to obtain 0.27 g of 5-(2,2-dimethyl-1,3-dioxolane-4-yl)methoxy-3-(4-methylbenzyl)thio-1,2,4-thiadiazole.

Provenance & Evidence