tert-Butyl 4-azido-3-hydroxypiperidine-1-carboxylate → tert-Butyl 4-amino-3-hydroxypiperidine-1-carboxylate

関与物質

反応手順

tert-Butyl 4-azido-3-hydroxypiperidine-1-carboxylate (62 g) obtained in Step 3 was dissolved in 300 ml of methanol. The mixture was hydrogenated with 10%-palladuim at room temperature under 35 psi for about 48 hours and filtered. The resulting filtrate was concentrated to give the titled compound (55 g) as a colorless and oily form.

情報源と証拠