反应详情

To the solution of methyl 1-[N-(benzofuran-2-ylcarbonyl)amino]-1-cyclohexanecarboxylate (105.0 g) in 450 ml of methanol, was added 2N-sodium hydroxide solution (170 ml, 0.34 mol). The reaction mixture was refluxed for 23 hours and concentrated to obtain a residue, which was diluted with 400 ml of water and washed with 300 ml of diethyl ether. 6N-hydrochloride was added dropwise to the resulting aqueous layer to adjust the pH of the solution to pH 3. The resulting white solid was filtered and dried to give the titled compound (49.5 g).

1. temperatureThe reaction mixture was refluxed for 23 hours
2. concentrationconcentrated
3. customto obtain a residue, which
4. washwashed with 300 ml of diethyl ether
5. addition6N-hydrochloride was added dropwise to the resulting aqueous layer
6. filtrationThe resulting white solid was filtered
7. customdried