HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-nitrophenyl)piperidin-3-ol → 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-aminophenyl)piperidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-nitrophenyl)piperidin-3-ol | HCID 69315023 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-aminophenyl)piperidin-3-ol | HCID 69312998 | 98.7% |
Reaction Steps
4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-nitrophenyl)piperidin-3-ol (7.0 g) obtained in Step 1 was dissolved in 30 ml of methanol. The solution was stirred with 10%-palladium catalyst overnight under 30 psi hydrogen atmosphere, and then filtered and concentrated to give 6.5 g of titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07342027B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-f100b77a0e8349a19d37d65ca03428dd |
| Source note | uspto-grants-2008_03 |